The Great Desert is a vast desert area with sand as far as the eye can see. It is home to the great Elder Dragon, Jhen Mohran and its subspecies, Hallowed Jhen Mohran. Dah'ren Mohran is also fought here. Delex and Remobra are the only small monsters that appear here.
- In the first area, birds can be seen flying around in the sky.
- In Monster Hunter 4, there are no areas that you can use to ledge jump except for the area on the Dragonship that has the Dragonator, and off the ship.
- The area behind the Dragonship in area 2 is different in Monster Hunter 3/Monster Hunter 3 Ultimate than in Monster Hunter 4. In third generation, the city in the distance is Loc Lac City. In fourth generation, it is Val Habar.